Cutaneous Granulomas in a Patient with Common Variable Immunodeficiency

Cutaneous granulomas in a patient with common variable immunodeficiency.

Sir, Common variable immunode¢ciency (CVID), one of the most frequent of the primary speci¢c immunode¢ciencies, is a heterogeneous group of syndromes characterized by a de¢ciency in antibody synthesis associated with panhypogammaglobulinaemia and recurrent bacterial infections (1). The occurrence of non-caseating granulomas in di¡erent organs, including the skin, has been described previously. ...

Cutaneous granulomas in common variable immunodeficiency: case report and review of literature.

Common variable immunodeficiency (CVID) is a heterogeneous disease characterized by recurrent infections, autoimmunity, malignancies, and granulomatous inflammation. Granulomatous lesion is one of the important manifestations of CVID, which continues to be unknown to many clinicians. While noncaseating granulomatous lesions can be detected in lungs, liver, spleen or conjunctiva of CVID patients...

Severe bronchiectasis in a patient with common variable immunodeficiency.

BACKGROUND Bronchiectasis are common in Common Variable Immunodeficiency. These patients are prone to infection, leading to progressive lung destruction and accelerated FEV1 decline. CLINICAL CASE 40 year-old man, with recurrent respiratory infections, autoimmunity and diarrhea since age 7. At 17 CVID was diagnosed and IVIgG was started. During the following years, respiratory symptoms progre...

Nocardiosis in a patient with common variable immunodeficiency.

We report a case of nocardiosis in a 42, years male with common variable immunodeficiency syndrome (CVID). He presented with arthritis, subcutaneous abscess and pleural effusion. Diagnosis of CVID was made during this presentation. Serum IgG, IgA and IgM levels were markedly decreased. Nocardia asteroides was cultured from pleural fluid. He was successfully treated with intravenous immunoglobul...

Secondary Amenorrhea in a Patient with Common Variable Immunodeficiency